Chinese researchers have reported the discovery of a new bacterial transfer RNA (tRNA) species, which can help the synthesis of antibiotics, according to the Chinese Academy of Sciences (CAS). This was reported by The Xinhua News Agency.
A research team from the Northwest Institute of Eco-Environment and Resources (NIEER) under the CAS discovered the tRNA-Asp-AUC from a fast-growing desert streptomycete, decoding GAU codons, and finding its functional characterization.
"The study provides an effective strategy to increase antibiotic production and to expand the repertoire of much-needed new bioactive metabolites produced by these valuable bacteria", – said Liu Guangxiu, a NIEER researcher and leader of the study.
Soil microorganisms can produce diverse secondary metabolites, which have great potential in producing the synthesis of antibiotics.
Streptomycete is a kind of microorganism, which can produce various kinds of secondary metabolites of value in clinical treatment, animal husbandry and growing inset-resistant crops.
"The new study results establish a new paradigm of inefficient wobble base-pairing involving GAU codons as an evolved strategy to regulate gene expression and, in particular, antibiotic biosynthesis", – said Liu.
The study results have been published in the journal Nucleic Acids Research.
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